Respiratory chain complex II as general sensor for apoptosis
نویسندگان
چکیده
منابع مشابه
High Molecular Weight Forms of Mammalian Respiratory Chain Complex II
Mitochondrial respiratory chain is organised into supramolecular structures that can be preserved in mild detergent solubilisates and resolved by native electrophoretic systems. Supercomplexes of respiratory complexes I, III and IV as well as multimeric forms of ATP synthase are well established. However, the involvement of complex II, linking respiratory chain with tricarboxylic acid cycle, in...
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Cu(II) complex with L-histidine (His) ligand, immobilized within Al-MCM-41, designated as Cu(His)2/Al-MCM-41 was prepared and characterized by powder X-ray diffraction (XRD), nitrogen adsorption desorption, FTIR, UV-Vis and chemical analysis techniques. The surface area and pore volume were found to decrease after immobilization of Cu(II) complex on Al-MCM-41. It was found that Cu(His)2/Al-MCM-...
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Mitochondrial dysfunction and dysregulation of apoptosis are implicated in many diseases such as cancer and neurodegeneration. We investigate here the role of respiratory chain (RC) dysfunction in apoptosis, using mitochondrial DNA mutations as genetic models. Although some mutations eliminate the entire RC, others target specific complexes, resulting in either decreased or complete loss of ele...
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ژورنال
عنوان ژورنال: Biochimica et Biophysica Acta (BBA) - Bioenergetics
سال: 2013
ISSN: 0005-2728
DOI: 10.1016/j.bbabio.2012.09.009